Tert-Butyldiptert-Butyldiphenylchlorosilane is a synthetic organic compound that acts as a silylating reagent, protecting alcohols, and preparing silyl ethers. It is a key raw material in organic synthesis, and is commonly used for the synthesis of interphenylene phenyloxazoles, which are used to treat circulatory disorders such as angina. It is immiscible with water, but is very moisture-sensitive.
Preparation
The preparation of tert-Butyldipphenylchlorosilane involves adding t-Butyllithium to a solution of diphenyldichlorosilane in 300 mL of redistilled pentane. Then, under nitrogen pressure, the solution of t-Butyllithium to the dropping funnel is added slowly while stirring with a stainless steel double-tip transfer needle.
Function
Tert-Butyldiphenyl chlorosilane is a silylating reagent that protects alcohols and prepares silyl ethers. It is a major raw material in the production of interphenylene phenyloxazoles. These drugs are used in the treatment of circulatory disorders and angina. These chemicals are incompatible with strong oxidizing agents.
Tert-Butyldiphenyl chlorosilane is a colourless oil with an molar mass of 240 g/mol. Its pKa is 2.4 and its c value is 0.4. Tert-Butyldiphenylchlorosilane was synthesized as a chemical reagent in the 1950s.
Cleavage
In the present invention, tert-Butyldiphenyl chlorosilane and CAS:18395-30-7 is used as a silylating reagent for the preparation of various silyl ethers. Among its major uses is in the production of interphenylene phenyloxazoles, which are useful drugs for circulatory disorders and angina. The silylating agent is incompatible with strong oxidizing agents.
Approximately eight grams of N2-N-dimethylamino-L-neopterin were suspended in 200 ml of dry N,N-dimethylformamide. The mixture was heated to 80deg C. After three hours, a solid was separated. The solid was collected, washed with 100 ml of ethanol and dried under vacuum at 40deg C. After 24 hours, a solid yield of 5 g of 3′(t-butyl-diphenylsilyl)-L-neopterin was obtained.